All national actors of the supply chain (producer, distributor, importer and user), within the scope of the declaration of substances at nanoscale, must make a declaration if they produce, import or distribute a substance, a mixture or a material answering the conditions laid down in the article R. 523-12. This déclaration is related to substance at nanoscale produced, distributed or imported in France. It entered into force on 1 January 2013 and is mandatory above 100 grams/year for each substance. In this declaration, It should be specified the identity of the registrant, the quantity, the physical-chemical properties, uses and the identity of professional users. The declaration must be completed before the 1 January of each year by electronic route (https://www.r-nano.fr) with the ANSES (“Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail”). The annual balance sheets of the imported, manufactured or distributed substances in France are available on the r-nano website. In 2015, 14580 substances have been declared, 40 % more than in 2014.